1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
2. Round | 03/08/2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
3. Round | 08/08/2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
13. Round | 17/10/2021 | Atlético San Luis | - | CF América | 0:1 |