| 1. Round | 17/02/2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 | ||||
| 2. Round | 23/02/2022 | Rangers | - | Deportes Melipilla | 1:0 |  |
|||
| 4. Round | 11/03/2022 | Recoleta | - | Deportes Melipilla | 1:2 |  |
|||
| 5. Round | 16/03/2022 | Deportes Melipilla | - | Deportes Copiapó | 2:1 | ||||
| 6. Round | 23/03/2022 | Unión San Felipe | - | Deportes Melipilla | 1:0 | |
|||
| 8. Round | 09/04/2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 26. Round | 31/08/2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 27. Round | 06/09/2022 | Santiago Wanderers | - | Deportes Melipilla | 2:2 | ||||
| 28. Round | 13/09/2022 | Deportes Melipilla | - | Deportes Temuco | 0:1 | ||||
| 29. Round | 24/09/2022 | Barnechea | - | Deportes Melipilla | 4:2 | ||||
| 30. Round | 03/10/2022 | Deportes Melipilla | - | Fernández Vial | 2:2 | ||||
| 31. Round | 09/10/2022 | CD Magallanes | - | Deportes Melipilla | 7:0 | ||||
| 32. Round | 17/10/2022 | Deportes Melipilla | - | Santiago Morning | 2:1 |
Chile