| Round of 16 | 01/12/2021 | AE Lárissa | - | PAOK Saloniki | 1:1 | ||||
| Round of 16 | 22/12/2021 | PAOK Saloniki | - | AE Lárissa | 3:1 | ||||
| Quarter-finals | 19/01/2022 | PAOK Saloniki | - | AEK Athen | 0:0 | ||||
| Quarter-finals | 09/02/2022 | AEK Athen | - | PAOK Saloniki | 1:2 | ||||
| Semi-finals | 21/04/2022 | PAOK Saloniki | - | Olympiakos Piraeus | 0:0 | ||||
| Semi-finals | 27/04/2022 | Olympiakos Piraeus | - | PAOK Saloniki | 1:1 aet |  |
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| Final | 21/05/2022 | Panathinaikos | - | PAOK Saloniki | 1:0 | |
Serbia