| 1. Round | 23/07/2021 | FK Lviv | - | FK Mariupol | 1:1 |  |
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| 2. Round | 01/08/2021 | FK Mariupol | - | Desna Chernigov | 1:2 | |
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| 3. Round | 07/08/2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 | ||||
| 4. Round | 16/08/2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | |
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| 5. Round | 22/08/2021 | FK Mariupol | - | Zorya Lugansk | 3:4 | |
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| 6. Round | 28/08/2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Round | 12/09/2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | |
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| 9. Round | 25/09/2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 10. Round | 01/10/2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 11. Round | 16/10/2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | |
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| 12. Round | 23/10/2021 | NK Veres | - | FK Mariupol | 2:0 |
Ukraine