| 2. Round | 20/08/2000 | 1. FSV Mainz 05 | - | Stuttgarter Kickers | 2:2 | ||||
| 8. Round | 14/10/2000 | 1. FSV Mainz 05 | - | 1. FC Saarbrücken | 1:0 | ||||
| 9. Round | 22/10/2000 | VfL Osnabrück | - | 1. FSV Mainz 05 | 2:1 | ||||
| 10. Round | 28/10/2000 | 1. FSV Mainz 05 | - | SSV Ulm 1846 | 0:3 | ||||
| 11. Round | 04/11/2000 | Rot-Weiß Oberhausen | - | 1. FSV Mainz 05 | 1:0 | ||||
| 12. Round | 11/11/2000 | 1. FSV Mainz 05 | - | Hannover 96 | 0:2 | ||||
| 13. Round | 17/11/2000 | 1. FSV Mainz 05 | - | Alemannia Aachen | 1:1 |  |
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| 31. Round | 28/04/2001 | 1. FSV Mainz 05 | - | FC St. Pauli | 1:1 | ||||
| 32. Round | 06/05/2001 | 1. FC Nürnberg | - | 1. FSV Mainz 05 | 1:0 | ||||
| 34. Round | 20/05/2001 | Waldhof Mannheim | - | 1. FSV Mainz 05 | 4:0 |
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