| 1. Round | 12/07/2022 | Deportivo Guadalajara [Women] | - | Club Tijuana [Women] | 2:1 | ||||
| 2. Round | 17/07/2022 | Deportivo Guadalajara [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 10. Round | 28/08/2022 | Deportivo Guadalajara [Women] | - | Mazatlán FC [Women] | 7:0 |  |
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| 11. Round | 11/09/2022 | Puebla FC [Women] | - | Deportivo Guadalajara [Women] | 2:3 | ||||
| 12. Round | 20/09/2022 | Deportivo Guadalajara [Women] | - | UANL Tigres [Women] | 1:0 | ||||
| 13. Round | 23/09/2022 | Pumas UNAM [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 14. Round | 26/09/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 15. Round | 03/10/2022 | Deportivo Guadalajara [Women] | - | CF América [Women] | 2:2 | ||||
| 16. Round | 18/10/2022 | CF Monterrey [Women] | - | Deportivo Guadalajara [Women] | 1:0 |
Mexico