13. Round | 02/04/2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
14. Round | 06/04/2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 | ||||
16. Round | 23/04/2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
17. Round | 30/04/2022 | Club León [] | - | CF Monterrey [] | 1:1 | ||||
15. Round | 03/05/2022 | Atlético San Luis [] | - | Club León [] | 0:3 | ||||
18. Round | 07/05/2022 | Santos Laguna [] | - | Club León [] | 2:3 |