2. Round | 13/02/2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
3. Round | 18/02/2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
4. Round | 26/02/2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
5. Round | 06/03/2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
6. Round | 12/03/2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
9. Round | 16/04/2022 | Universitario de Sucre | - | Real Santa Cruz | 2:3 | ||||
11. Round | 24/04/2022 | Real Santa Cruz | - | Nacional Potosí | 3:2 | ||||
12. Round | 30/04/2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
15. Round | 14/05/2022 | Oriente Petrolero | - | Real Santa Cruz | 1:2 |