| 1. Round | 17/01/2021 | Leones Negros | - | Coyotes de Tlaxcala | 1:1 | ||||
| 2. Round | 21/01/2021 | TM Fútbol Club | - | Leones Negros | 0:0 | ||||
| 3. Round | 29/01/2021 | Leones Negros | - | Dorados de Sinaloa | 0:1 | ||||
| 4. Round | 03/02/2021 | Pumas Tabasco | - | Leones Negros | 2:0 | ||||
| 6. Round | 17/02/2021 | Correcaminos UAT | - | Leones Negros | 0:2 | ||||
| 7. Round | 25/02/2021 | Leones Negros | - | Atlante | 0:3 |  |
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| 12. Round | 29/03/2021 | Mineros de Zacatecas | - | Leones Negros | 1:0 | ||||
| 13. Round | 02/04/2021 | Leones Negros | - | Club Celaya | 3:1 | ||||
| 15. Round | 14/04/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 | |
Mexico