| 1. Round | 08/01/2022 | Puebla FC | - | CF América | 1:1 | ||||
| 3. Round | 29/01/2022 | Puebla FC | - | Club Tijuana | 3:1 | ||||
| 7. Round | 27/02/2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
| 12. Round | 03/04/2022 | Deportivo Toluca | - | Puebla FC | 2:1 |  |
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| 14. Round | 16/04/2022 | Club León | - | Puebla FC | 0:1 | ||||
| 15. Round | 20/04/2022 | CF Pachuca | - | Puebla FC | 1:0 |
Mexico