| 1. Round | 06/01/2018 | Atlas Guadalajara | - | Club León | 1:2 | ||||
| 2. Round | 14/01/2018 | Pumas UNAM | - | Atlas Guadalajara | 3:1 | ||||
| 3. Round | 20/01/2018 | Atlas Guadalajara | - | Deportivo Toluca | 1:3 | ||||
| 4. Round | 28/01/2018 | CF América | - | Atlas Guadalajara | 1:0 | ||||
| 5. Round | 03/02/2018 | Atlas Guadalajara | - | Cruz Azul | 2:1 | ||||
| 6. Round | 10/02/2018 | Lobos BUAP | - | Atlas Guadalajara | 3:1 | ||||
| 7. Round | 14/02/2018 | Atlas Guadalajara | - | Club Necaxa | 1:1 | ||||
| 8. Round | 18/02/2018 | UANL Tigres | - | Atlas Guadalajara | 2:0 | ||||
| 9. Round | 24/02/2018 | Atlas Guadalajara | - | CF Monterrey | 0:1 | ||||
| 10. Round | 03/03/2018 | Monarcas Morelia | - | Atlas Guadalajara | 2:1 | ||||
| 11. Round | 10/03/2018 | Atlas Guadalajara | - | Puebla FC | 1:0 | ||||
| 12. Round | 19/03/2018 | CD Veracruz | - | Atlas Guadalajara | 3:1 | ||||
| 13. Round | 31/03/2018 | Atlas Guadalajara | - | Santos Laguna | 3:2 | ||||
| 14. Round | 07/04/2018 | Club Tijuana | - | Atlas Guadalajara | 2:2 |  |
|||
| 15. Round | 14/04/2018 | Atlas Guadalajara | - | Gallos Blancos | 1:0 |  |
|||
| 16. Round | 21/04/2018 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:0 | ||||
| 17. Round | 29/04/2018 | CF Pachuca | - | Atlas Guadalajara | 0:0 |
Chile