| 1. Round | 19/02/2022 | LDU Quito | - | Gualaceo SC | 1:0 | ||||
| 2. Round | 27/02/2022 | Gualaceo SC | - | Cumbayá | 0:1 | ||||
| 3. Round | 08/03/2022 | Deportivo Cuenca | - | Gualaceo SC | 2:1 | ||||
| 5. Round | 20/03/2022 | 9 de Octubre | - | Gualaceo SC | 1:1 |  |
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| 9. Round | 21/04/2022 | Barcelona | - | Gualaceo SC | 0:1 | ||||
| 14. Round | 21/05/2022 | Delfín SC | - | Gualaceo SC | 1:0 |
Ecuador