| 5. Round | 07/02/2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Round | 11/02/2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 | ||||
| 8. Round | 18/02/2021 | Progreso | - | Nacional | 0:1 |  |
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| 10. Round | 02/03/2021 | Progreso | - | Deportivo Maldonado | 1:1 | ||||
| 11. Round | 08/03/2021 | Rentistas | - | Progreso | 1:3 | ||||
| 12. Round | 14/03/2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 13. Round | 21/03/2021 | Montevideo Wanderers | - | Progreso | 3:0 dec. | ||||
| 14. Round | 25/03/2021 | Progreso | - | Peñarol | 0:2 | ||||
| 15. Round | 29/03/2021 | River Plate | - | Progreso | 3:2 |
Uruguay