| 1. Round | 01/06/2021 | Albion | - | CA Cerro | 1:2 | ||||
| 2. Round | 10/06/2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Round | 16/06/2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 7. Round | 15/07/2021 | Juventud de Las Piedras | - | CA Cerro | 3:1 | ||||
| 8. Round | 21/07/2021 | CA Cerro | - | Uruguay Montevideo | 0:1 | ||||
| 9. Round | 31/07/2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Round | 06/08/2021 | CA Cerro | - | Danubio | 1:1 | ||||
| 11. Round | 12/08/2021 | Rocha | - | CA Cerro | 1:3 |  |
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| 12. Round | 17/09/2021 | CA Cerro | - | Albion | 1:0 |  |
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| 13. Round | 23/09/2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Round | 28/09/2021 | CA Cerro | - | Central Español | 0:0 | |
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| 15. Round | 04/10/2021 | Atenas | - | CA Cerro | 1:2 | ||||
| 16. Round | 14/10/2021 | CA Cerro | - | Racing | 1:0 | ||||
| 17. Round | 19/10/2021 | Villa Teresa | - | CA Cerro | 1:2 | ||||
| 18. Round | 28/10/2021 | CA Cerro | - | Juventud de Las Piedras | 2:1 | ||||
| 19. Round | 03/11/2021 | Uruguay Montevideo | - | CA Cerro | 1:2 | ||||
| 20. Round | 10/11/2021 | CA Cerro | - | Rampla Juniors | 1:2 | ||||
| 21. Round | 18/11/2021 | Danubio | - | CA Cerro | 0:0 | |
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| 22. Round | 24/11/2021 | CA Cerro | - | Rocha | 3:0 |
Uruguay