1. Round | 10/02/2022 | Universidad Cesar Vallejo | - | Club Olimpia | 0:1 | ||||
1. Round | 17/02/2022 | Club Olimpia | - | Universidad Cesar Vallejo | 2:0 | ||||
2. Round | 25/02/2022 | Club Olimpia | - | Atlético Nacional | 3:1 | ||||
2. Round | 04/03/2022 | Atlético Nacional | - | Club Olimpia | 1:1 | ||||
3. Round | 10/03/2022 | Fluminense RJ | - | Club Olimpia | 3:1 | ||||
3. Round | 17/03/2022 | Club Olimpia | - | Fluminense RJ | 2:0 pso | ||||
Group G | 05/04/2022 | Club Olimpia | - | Cerro Porteño | 0:0 | ||||
Group G | 13/04/2022 | Peñarol | - | Club Olimpia | 2:1 |