| 1. Round | 11/07/2021 | Metallurg Lipetsk | - | FK Tom Tomsk | 3:2 | ||||
| 2. Round | 17/07/2021 | FK Orenburg | - | Metallurg Lipetsk | 4:0 | ||||
| 3. Round | 25/07/2021 | Metallurg Lipetsk | - | Akron Tolyatti | 2:2 | ||||
| 4. Round | 31/07/2021 | FK Neftekhimik | - | Metallurg Lipetsk | 5:0 | ||||
| 5. Round | 08/08/2021 | Metallurg Lipetsk | - | Rotor Volgograd | 0:1 | ||||
| 6. Round | 14/08/2021 | FK Kamaz | - | Metallurg Lipetsk | 3:0 | ||||
| 7. Round | 21/08/2021 | Metallurg Lipetsk | - | FK Krasnodar 2 | 1:2 | ||||
| 8. Round | 29/08/2021 | Torpedo Moskva | - | Metallurg Lipetsk | 7:1 | ||||
| 9. Round | 05/09/2021 | Metallurg Lipetsk | - | Enisey Krasnoyarsk | 0:2 | ||||
| 10. Round | 11/09/2021 | Kuban Krasnodar | - | Metallurg Lipetsk | 0:3 | ||||
| 18. Round | 17/10/2021 | Metallurg Lipetsk | - | Baltika Kaliningrad | 0:4 | ||||
| 20. Round | 31/10/2021 | Metallurg Lipetsk | - | FK Orenburg | 1:0 | ||||
| 23. Round | 17/11/2021 | Rotor Volgograd | - | Metallurg Lipetsk | 0:1 | ||||
| 24. Round | 21/11/2021 | Metallurg Lipetsk | - | FK Kamaz | 0:1 | ||||
| 25. Round | 27/11/2021 | FK Krasnodar 2 | - | Metallurg Lipetsk | 1:0 |
Russia