| 7. Round | 29/08/2021 | FK Tyumen | - | Torpedo Miass | 8:1 |  |
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| 8. Round | 06/09/2021 | FK Orenburg 2 | - | FK Tyumen | 3:7 | |
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| 9. Round | 12/09/2021 | FK Tyumen | - | FK Ural 2 | 2:1 | ||||
| 10. Round | 18/09/2021 | Nosta Novotroitsk | - | FK Tyumen | 1:1 | |
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| 11. Round | 26/09/2021 | Zenit Izhevsk | - | FK Tyumen | 0:4 | ||||
| 12. Round | 30/09/2021 | Zvezda Perm | - | FK Tyumen | 3:0 | ||||
| 16. Round | 23/10/2021 | FK Tyumen | - | Lada Tolyatti | 7:0 | |
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| 17. Round | 31/10/2021 | Volga Ulyanovsk | - | FK Tyumen | 3:2 | |
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| 18. Round | 04/11/2021 | FK Chelyabinsk | - | FK Tyumen | 0:0 | ||||
| 21. Round | 03/04/2022 | FK Tyumen | - | Nosta Novotroitsk | 1:1 | ||||
| 22. Round | 11/04/2022 | FK Ural 2 | - | FK Tyumen | 2:2 | ||||
| 23. Round | 17/04/2022 | FK Tyumen | - | FK Orenburg 2 | 4:0 | |
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| 24. Round | 24/04/2022 | Torpedo Miass | - | FK Tyumen | 0:3 | |
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| 25. Round | 05/05/2022 | FK Tyumen | - | Irtysh Omsk | 7:2 | |
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| 26. Round | 08/05/2022 | FK Tyumen | - | Dinamo Barnaul | 3:0 | ||||
| 27. Round | 15/05/2022 | Spartak Tuymazy | - | FK Tyumen | 1:4 | ||||
| 28. Round | 21/05/2022 | FK Tyumen | - | FK Amkar Perm | 1:0 | ||||
| 29. Round | 28/05/2022 | FK Novosibirsk | - | FK Tyumen | 0:4 | |
Russia