| 4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Round | 06/03/2022 | Libertad | - | Sportivo Ameliano | 2:0 | ||||
| 6. Round | 14/03/2022 | Club Nacional | - | Libertad | 0:3 | ||||
| 7. Round | 20/03/2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 9. Round | 10/04/2022 | Libertad | - | Sol de América | 3:1 | ||||
| 10. Round | 17/04/2022 | Cerro Porteño | - | Libertad | 4:0 | ||||
| 11. Round | 21/04/2022 | Libertad | - | Resistencia SC | 2:2 | ||||
| 12. Round | 23/04/2022 | Libertad | - | 12 de Octubre de Itauguá | 4:0 | ||||
| 18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 | ||||
| 20. Round | 21/06/2022 | Sol de América | - | Libertad | 0:3 | ||||
| 22. Round | 03/07/2022 | Resistencia SC | - | Libertad | 0:4 |
Paraguay