| 2. Round | 29/07/2019 | Deportivo Guadalajara | - | UANL Tigres | 2:0 |  |
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| 3. Round | 03/08/2019 | Puebla FC | - | Deportivo Guadalajara | 1:1 |  |
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| 4. Round | 11/08/2019 | Deportivo Guadalajara | - | Atlético San Luis | 3:0 | ||||
| 5. Round | 18/08/2019 | Club León | - | Deportivo Guadalajara | 4:3 | ||||
| 6. Round | 25/08/2019 | Deportivo Guadalajara | - | Club Necaxa | 1:2 | |
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| 8. Round | 01/09/2019 | Cruz Azul | - | Deportivo Guadalajara | 1:1 | |
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| 9. Round | 15/09/2019 | Deportivo Guadalajara | - | Atlas Guadalajara | 1:0 | ||||
| 10. Round | 21/09/2019 | Monarcas Morelia | - | Deportivo Guadalajara | 1:0 | ||||
| 11. Round | 25/09/2019 | Deportivo Guadalajara | - | CF Pachuca | 2:4 | ||||
| 12. Round | 29/09/2019 | CF América | - | Deportivo Guadalajara | 4:1 |  |
Mexico