| 1. Round | 09/01/2022 | Coyotes de Tlaxcala | - | Atlético Morelia | 0:4 | ||||
| 4. Round | 25/01/2022 | Tepatitlán | - | Coyotes de Tlaxcala | 1:1 | ||||
| 8. Round | 15/02/2022 | Coyotes de Tlaxcala | - | Club Celaya | 0:1 | ||||
| 14. Round | 28/03/2022 | Mineros de Zacatecas | - | Coyotes de Tlaxcala | 3:4 |  |
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| 15. Round | 31/03/2022 | Coyotes de Tlaxcala | - | CF Monterrey II | 2:1 | ||||
| 16. Round | 07/04/2022 | Cancún FC | - | Coyotes de Tlaxcala | 1:0 | |
Mexico