| 1. Round | 31/07/2005 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 2. Round | 06/08/2005 | Atlante | - | Santos Laguna | 0:0 | ||||
| 3. Round | 14/08/2005 | Santos Laguna | - | UANL Tigres | 1:4 |  |
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| 4. Round | 21/08/2005 | Dorados de Sinaloa | - | Santos Laguna | 0:3 |  |
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| 5. Round | 25/08/2005 | CF América | - | Santos Laguna | 2:1 | ||||
| 6. Round | 28/08/2005 | Santos Laguna | - | Deportivo Guadalajara | 3:0 | ||||
| 7. Round | 11/09/2005 | Club Necaxa | - | Santos Laguna | 4:3 | ||||
| 8. Round | 18/09/2005 | Santos Laguna | - | Club San Luis | 3:1 | ||||
| 9. Round | 24/09/2005 | Veracruz (old) | - | Santos Laguna | 2:2 | ||||
| 10. Round | 29/09/2005 | Santos Laguna | - | Cruz Azul | 3:2 | ||||
| 11. Round | 01/10/2005 | CF Monterrey | - | Santos Laguna | 2:2 | |
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| 12. Round | 16/10/2005 | Santos Laguna | - | CF Pachuca | 0:0 | ||||
| 13. Round | 22/10/2005 | Monarcas Morelia | - | Santos Laguna | 1:0 | ||||
| 14. Round | 30/10/2005 | Santos Laguna | - | Atlas Guadalajara | 2:2 | ||||
| 15. Round | 05/11/2005 | UAG Tecos | - | Santos Laguna | 3:2 |
Mexico