| 4. Round | 06/02/2010 | Cruz Azul | - | Santos Laguna | 0:2 | ||||
| 9. Round | 07/03/2010 | Santos Laguna | - | Atlante | 4:2 | ||||
| 10. Round | 14/03/2010 | CF Pachuca | - | Santos Laguna | 0:3 |  |
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| 11. Round | 21/03/2010 | Santos Laguna | - | Puebla FC | 2:1 | |
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| 12. Round | 28/03/2010 | Deportivo Guadalajara | - | Santos Laguna | 6:2 | ||||
| 13. Round | 04/04/2010 | Santos Laguna | - | Jaguares Chiapas | 0:3 | |
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| 14. Round | 11/04/2010 | Pumas UNAM | - | Santos Laguna | 1:0 | ||||
| 15. Round | 15/04/2010 | Santos Laguna | - | CF Monterrey | 1:1 | ||||
| 16. Round | 20/04/2010 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 17. Round | 25/04/2010 | CF América | - | Santos Laguna | 1:0 |
Mexico