| 1. Round | 09/01/2011 | Santos Laguna | - | Atlante | 2:1 | ||||
| 2. Round | 16/01/2011 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 3. Round | 23/01/2011 | Santos Laguna | - | CF Pachuca | 1:1 | ||||
| 4. Round | 29/01/2011 | Jaguares Chiapas | - | Santos Laguna | 1:2 | ||||
| 5. Round | 06/02/2011 | Santos Laguna | - | UANL Tigres | 0:2 |  |
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| 6. Round | 13/02/2011 | Atlas Guadalajara | - | Santos Laguna | 1:2 | ||||
| 7. Round | 20/02/2011 | Santos Laguna | - | Gallos Blancos (old) | 0:2 | ||||
| 8. Round | 26/02/2011 | Club Necaxa | - | Santos Laguna | 1:0 | ||||
| 9. Round | 06/03/2011 | Santos Laguna | - | CF América | 2:3 | ||||
| 10. Round | 13/03/2011 | Deportivo Toluca | - | Santos Laguna | 3:1 |
Mexico