| 3. Round | 27/09/2020 | OFI Heraklion | - | Atromitos | 2:2 | ||||
| 4. Round | 04/10/2020 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
| 5. Round | 18/10/2020 | OFI Heraklion | - | Panathinaikos | 2:2 | ||||
| 6. Round | 25/10/2020 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
| 7. Round | 01/11/2020 | AEK Athen | - | OFI Heraklion | 2:1 | ||||
| 8. Round | 08/11/2020 | OFI Heraklion | - | Olympiakos Piraeus | 0:2 | ||||
| 9. Round | 23/11/2020 | Volos NFC | - | OFI Heraklion | 1:4 | ||||
| 10. Round | 29/11/2020 | OFI Heraklion | - | PAS Giannina | 2:1 | ||||
| 11. Round | 06/12/2020 | OFI Heraklion | - | Apollon Smyrnis | 0:2 | ||||
| 12. Round | 12/12/2020 | AE Lárissa | - | OFI Heraklion | 0:1 | ||||
| 13. Round | 19/12/2020 | OFI Heraklion | - | Aris Saloniki | 0:3 |
Greece
