| 1. Round | 17/09/2000 | OFI Heraklion | - | Aris Saloniki | 2:3 | ||||
| 2. Round | 23/09/2000 | Aris Saloniki | - | Paniliakos Pyrgos | 1:0 | ||||
| 3. Round | 30/09/2000 | Panathinaikos | - | Aris Saloniki | 2:2 | ||||
| 5. Round | 04/11/2000 | Skoda Xanthi | - | Aris Saloniki | 1:0 | ||||
| 6. Round | 11/11/2000 | Aris Saloniki | - | Iraklis Saloniki | 0:2 | ||||
| 12. Round | 02/01/2001 | PS Kalamata | - | Aris Saloniki | 1:1 |  |
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| 13. Round | 06/01/2001 | Aris Saloniki | - | PAS Giannina | 1:0 | |
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| 15. Round | 20/01/2001 | Olympiakos Piraeus | - | Aris Saloniki | 4:1 | ||||
| 16. Round | 26/01/2001 | Aris Saloniki | - | OFI Heraklion | 2:0 |  |
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| 26. Round | 19/04/2001 | Panachaiki GE | - | Aris Saloniki | 4:1 |
Greece