4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
5. Round | 07/03/2022 | 12 de Octubre de Itauguá | - | Guaraní | 1:3 | ||||
17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 | ||||
21. Round | 26/06/2022 | Club Nacional | - | Guaraní | 0:1 |