| 1. Round | 21/01/2006 | UAG Tecos | - | Club San Luis | 2:1 |  |
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| 2. Round | 29/01/2006 | Club San Luis | - | Deportivo Toluca | 1:3 | |
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| 3. Round | 01/02/2006 | Jaguares Chiapas | - | Club San Luis | 1:1 | |
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| 4. Round | 05/02/2006 | Club San Luis | - | Pumas UNAM | 3:0 | |
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| 5. Round | 11/02/2006 | Atlante | - | Club San Luis | 1:1 | ||||
| 6. Round | 19/02/2006 | Club San Luis | - | UANL Tigres | 0:0 | ||||
| 7. Round | 25/02/2006 | Dorados de Sinaloa | - | Club San Luis | 1:0 | ||||
| 8. Round | 05/03/2006 | Club San Luis | - | Santos Laguna | 1:1 | |
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| 9. Round | 12/03/2006 | Deportivo Guadalajara | - | Club San Luis | 1:3 | ||||
| 11. Round | 19/03/2006 | Club San Luis | - | CF América | 2:0 | |
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| 12. Round | 25/03/2006 | Veracruz (old) | - | Club San Luis | 3:0 | ||||
| 13. Round | 02/04/2006 | Club San Luis | - | Cruz Azul | 2:1 | |
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| 14. Round | 08/04/2006 | CF Monterrey | - | Club San Luis | 0:1 | |
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| 15. Round | 16/04/2006 | Club San Luis | - | CF Pachuca | 2:3 | |
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| 16. Round | 23/04/2006 | Monarcas Morelia | - | Club San Luis | 1:0 | ||||
| 17. Round | 30/04/2006 | Club San Luis | - | Atlas Guadalajara | 2:1 |
Argentina
Mexico