| 1. Round | 12/02/2000 | San Lorenzo | - | Newell's Old Boys | 1:0 |  |
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| 2. Round | 18/02/2000 | Unión de Santa Fe | - | San Lorenzo | 0:1 | |
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| 3. Round | 26/02/2000 | San Lorenzo | - | Gimnasia de La Plata | 1:1 | |
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| 4. Round | 04/03/2000 | Talleres de Córdoba | - | San Lorenzo | 1:2 | ||||
| 5. Round | 11/03/2000 | San Lorenzo | - | Racing Club | 1:0 | ||||
| 6. Round | 18/03/2000 | Chacarita Juniors | - | San Lorenzo | 0:0 |  |
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| 7. Round | 30/03/2000 | San Lorenzo | - | Ferro Carril Oeste | 4:0 | |
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| 8. Round | 08/04/2000 | San Lorenzo | - | Boca Juniors | 0:1 | ||||
| 9. Round | 10/04/2000 | Instituto de Córdoba | - | San Lorenzo | 1:0 | ||||
| 10. Round | 15/04/2000 | San Lorenzo | - | Rosario Central | 1:0 | |
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| 11. Round | 12/05/2000 | Colón de Santa Fe | - | San Lorenzo | 2:1 | ||||
| 12. Round | 18/05/2000 | San Lorenzo | - | Estudiantes | 3:0 | ||||
| 13. Round | 27/05/2000 | Belgrano de Córdoba | - | San Lorenzo | 1:2 | ||||
| 14. Round | 10/06/2000 | San Lorenzo | - | Independiente | 1:2 |
Argentina