| 1. Round | 08/07/2023 | Libertad | - | Club Nacional | 2:0 |  |
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| 2. Round | 18/07/2023 | Club Nacional | - | Tacuary | 1:1 | ||||
| 3. Round | 23/07/2023 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 4. Round | 29/07/2023 | Guaraní | - | Club Nacional | 1:1 | |
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| 5. Round | 06/08/2023 | Club Nacional | - | Guaireña FC | 2:0 | ||||
| 6. Round | 12/08/2023 | Sportivo Ameliano | - | Club Nacional | 2:0 | ||||
| 7. Round | 21/08/2023 | Club Nacional | - | General Caballero DJLM | 2:3 | ||||
| 10. Round | 11/09/2023 | Cerro Porteño | - | Club Nacional | 1:1 | ||||
| 11. Round | 16/09/2023 | Club Nacional | - | Sportivo Luqueño | 2:1 | ||||
| 12. Round | 24/09/2023 | Club Nacional | - | Libertad | 2:3 | ||||
| 14. Round | 08/10/2023 | Club Nacional | - | Club Olimpia | 1:0 | ||||
| 19. Round | 06/11/2023 | Club Nacional | - | Resistencia SC | 5:0 | ||||
| 21. Round | 26/11/2023 | Club Nacional | - | Cerro Porteño | 1:1 | ||||
| 22. Round | 01/12/2023 | Sportivo Luqueño | - | Club Nacional | 1:1 |
Paraguay