| Preliminary | 10/03/2022 | Unión Española | - | Antofagasta | 1:2 | ||||
| Preliminary | 17/03/2022 | Antofagasta | - | Unión Española | 4:1 pso | ||||
| Group F | 07/04/2022 | Antofagasta | - | Defensa y Justicia | 1:3 | ||||
| Group F | 13/04/2022 | LDU Quito | - | Antofagasta | 4:0 | ||||
| Group F | 18/05/2022 | Atlético Goianiense | - | Antofagasta | 1:0 |
Chile