| 5. Round | 19/10/2020 | Colima FC | - | Alacranes de Durango | 2:1 | ||||
| 6. Round | 24/10/2020 | Mazorqueros | - | Colima FC | 0:2 | ||||
| 7. Round | 10/11/2020 | Colima FC | - | Cimarrones de Sonora II | 2:0 | ||||
| 8. Round | 14/11/2020 | Atlético San Luis II | - | Colima FC | 2:0 | ||||
| 9. Round | 21/11/2020 | Colima FC | - | Saltillo FC | 3:0 | ||||
| 10. Round | 05/12/2020 | Colima FC | - | Reboceros de La Piedad | 0:3 | ||||
| 11. Round | 12/12/2020 | Leones Negros II | - | Colima FC | 0:2 |  |
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| 12. Round | 17/01/2021 | Gavilanes de Matamoros | - | Colima FC | 0:0 | ||||
| 13. Round | 23/01/2021 | Colima FC | - | Tecos Fútbol Club | 1:2 | ||||
| 14. Round | 30/01/2021 | Tuzos de la UAZ | - | Colima FC | 0:4 | |
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| 15. Round | 06/02/2021 | Colima FC | - | Mineros de Fresnillo FC | 1:2 | |
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| 16. Round | 13/02/2021 | Alacranes de Durango | - | Colima FC | 3:0 | ||||
| 17. Round | 20/02/2021 | Colima FC | - | Mazorqueros | 3:0 | ||||
| 19. Round | 14/03/2021 | Colima FC | - | Atlético San Luis II | 2:0 | ||||
| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 | |
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| 21. Round | 04/04/2021 | Reboceros de La Piedad | - | Colima FC | 1:0 |
Mexico