| 6. Round | 17/02/2008 | Atlas Guadalajara | - | CF América | 1:0 | ||||
| 7. Round | 24/02/2008 | CF América | - | Santos Laguna | 0:1 | ||||
| 8. Round | 02/03/2008 | UANL Tigres | - | CF América | 3:0 |  |
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| 9. Round | 09/03/2008 | CF América | - | Club San Luis | 1:2 | ||||
| 10. Round | 16/03/2008 | Cruz Azul | - | CF América | 2:2 |
Mexico