| 1. Round | 18/07/2021 | Nosta Novotroitsk | - | Spartak Tuymazy | 1:2 |  |
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| 3. Round | 01/08/2021 | Spartak Tuymazy | - | Lada Tolyatti | 7:2 | ||||
| 4. Round | 07/08/2021 | FK Tyumen | - | Spartak Tuymazy | 4:3 | ||||
| 8. Round | 05/09/2021 | Spartak Tuymazy | - | Zvezda Perm | 3:2 | ||||
| 10. Round | 17/09/2021 | Dinamo Barnaul | - | Spartak Tuymazy | 3:0 | ||||
| 14. Round | 10/10/2021 | Zenit Izhevsk | - | Spartak Tuymazy | 0:1 | ||||
| 15. Round | 17/10/2021 | Volga Ulyanovsk | - | Spartak Tuymazy | 1:0 | ||||
| 16. Round | 23/10/2021 | Spartak Tuymazy | - | Volga Ulyanovsk | 0:5 | ||||
| 17. Round | 31/10/2021 | Spartak Tuymazy | - | Zenit Izhevsk | 4:0 | ||||
| 19. Round | 09/11/2021 | FK Amkar Perm | - | Spartak Tuymazy | 4:1 | ||||
| 20. Round | 14/11/2021 | FK Chelyabinsk | - | Spartak Tuymazy | 2:4 |  |
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| 22. Round | 10/04/2022 | Spartak Tuymazy | - | Irtysh Omsk | 0:6 | ||||
| 21. Round | 13/04/2022 | Spartak Tuymazy | - | Dinamo Barnaul | 2:1 | ||||
| 24. Round | 24/04/2022 | Spartak Tuymazy | - | FK Orenburg 2 | 1:2 | ||||
| 26. Round | 08/05/2022 | FK Novosibirsk | - | Spartak Tuymazy | 5:1 | ||||
| 27. Round | 15/05/2022 | Spartak Tuymazy | - | FK Tyumen | 1:4 |
Russia