| 3. Round | 10/08/2024 | MŠK Žilina | - | MFK Zemplín Michalovce | 3:1 | ||||
| 6. Round | 31/08/2024 | KFC Komárno | - | MFK Zemplín Michalovce | 1:3 | ||||
| 14. Round | 09/11/2024 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:1 |  |
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| 15. Round | 23/11/2024 | FC DAC 1904 | - | MFK Zemplín Michalovce | 0:1 | ||||
| 16. Round | 30/11/2024 | MFK Zemplín Michalovce | - | MFK Ružomberok | 4:2 | ||||
| 17. Round | 07/12/2024 | MFK Zemplín Michalovce | - | KFC Komárno | 0:0 | ||||
| 18. Round | 14/12/2024 | AS Trenčín | - | MFK Zemplín Michalovce | 0:0 | ||||
| 19. Round | 08/02/2025 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 2:2 | ||||
| 20. Round | 15/02/2025 | Slovan Bratislava | - | MFK Zemplín Michalovce | 1:1 | ||||
| 21. Round | 23/02/2025 | MFK Zemplín Michalovce | - | Dukla Banská Bystrica | 1:0 |  |
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| 22. Round | 01/03/2025 | FC Košice | - | MFK Zemplín Michalovce | 3:2 |
Ukraine