| 1. Round | 23/02/2025 | Houston Dynamo | - | FC Dallas | 1:2 | ||||
| 2. Round | 03/03/2025 | Houston Dynamo | - | Inter Miami CF | 1:4 | ||||
| 3. Round | 08/03/2025 | Columbus Crew | - | Houston Dynamo | 0:0 |  |
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| 4. Round | 16/03/2025 | Houston Dynamo | - | Real Salt Lake | 1:2 | ||||
| 5. Round | 23/03/2025 | Seattle Sounders | - | Houston Dynamo | 0:0 | ||||
| 6. Round | 31/03/2025 | Portland Timbers | - | Houston Dynamo | 3:1 | ||||
| 7. Round | 06/04/2025 | Houston Dynamo | - | Los Angeles FC | 1:0 | ||||
| 8. Round | 13/04/2025 | Los Angeles Galaxy | - | Houston Dynamo | 1:1 | ||||
| 9. Round | 20/04/2025 | Houston Dynamo | - | Colorado Rapids | 2:2 | ||||
| 10. Round | 27/04/2025 | Houston Dynamo | - | Austin FC | 2:0 | ||||
| 11. Round | 04/05/2025 | Los Angeles FC | - | Houston Dynamo | 2:0 | ||||
| 12. Round | 11/05/2025 | Houston Dynamo | - | Seattle Sounders | 1:3 | |
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| 13. Round | 15/05/2025 | Houston Dynamo | - | Minnesota United FC | 2:0 | ||||
| 14. Round | 18/05/2025 | FC Dallas | - | Houston Dynamo | 0:2 | ||||
| 15. Round | 25/05/2025 | San Jose Earthquakes | - | Houston Dynamo | 3:3 | ||||
| 16. Round | 29/05/2025 | New York City FC | - | Houston Dynamo | 0:3 | ||||
| 17. Round | 01/06/2025 | Houston Dynamo | - | Sporting Kansas City | 1:3 |
Brazil
USA 