| 2. Round | 04/08/2020 | Club León | - | CF Monterrey | 1:0 | ||||
| 3. Round | 09/08/2020 | CF Monterrey | - | Santos Laguna | 2:2 | ||||
| 4. Round | 13/08/2020 | Pumas UNAM | - | CF Monterrey | 1:1 | ||||
| 5. Round | 16/08/2020 | CF Monterrey | - | Club Necaxa | 1:1 | ||||
| 11. Round | 21/09/2020 | Atlético San Luis | - | CF Monterrey | 1:2 | ||||
| 12. Round | 27/09/2020 | CF Monterrey | - | UANL Tigres | 0:2 | ||||
| 13. Round | 05/10/2020 | Gallos Blancos | - | CF Monterrey | 1:2 |  |
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| 14. Round | 17/10/2020 | CF Monterrey | - | Puebla FC | 3:1 | ||||
| 15. Round | 25/10/2020 | Mazatlán FC | - | CF Monterrey | 1:2 | ||||
| 16. Round | 01/11/2020 | CF Monterrey | - | Cruz Azul | 1:0 | ||||
| 17. Round | 07/11/2020 | Deportivo Guadalajara | - | CF Monterrey | 3:1 |  |
Mexico