| 4. Round | 31/07/2022 | Cumbayá | - | Mushuc Runa | 1:1 | ||||
| 5. Round | 08/08/2022 | Barcelona | - | Mushuc Runa | 4:1 | ||||
| 8. Round | 28/08/2022 | Mushuc Runa | - | Gualaceo SC | 2:0 | ||||
| 10. Round | 10/09/2022 | Mushuc Runa | - | LDU Quito | 1:2 |  |
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| 11. Round | 20/09/2022 | Guayaquil City | - | Mushuc Runa | 4:1 | |
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| 7. Round | 25/09/2022 | Delfín SC | - | Mushuc Runa | 0:0 | ||||
| 12. Round | 02/10/2022 | Mushuc Runa | - | Emelec | 0:0 | ||||
| 13. Round | 09/10/2022 | Aucas | - | Mushuc Runa | 0:0 | |
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| 14. Round | 17/10/2022 | Mushuc Runa | - | Independiente del Valle | 0:1 | ||||
| 15. Round | 22/10/2022 | Deportivo Cuenca | - | Mushuc Runa | 3:1 | |
Ecuador