| 1. Round | 19/09/2020 | Alacranes de Durango | - | Atlético San Luis II | 2:0 |  |
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| 4. Round | 10/10/2020 | Atlético San Luis II | - | Leones Negros II | 0:2 | ||||
| 6. Round | 24/10/2020 | Atlético San Luis II | - | Mineros de Fresnillo FC | 1:0 | ||||
| 7. Round | 09/11/2020 | Mazorqueros | - | Atlético San Luis II | 1:0 | ||||
| 10. Round | 06/12/2020 | Gavilanes de Matamoros | - | Atlético San Luis II | 1:0 |  |
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| 11. Round | 13/12/2020 | Atlético San Luis II | - | Tuzos de la UAZ | 1:1 | ||||
| 12. Round | 16/01/2021 | Atlético San Luis II | - | Alacranes de Durango | 1:1 | ||||
| 13. Round | 25/01/2021 | Cimarrones de Sonora II | - | Atlético San Luis II | 0:2 | ||||
| 16. Round | 13/02/2021 | Atlético San Luis II | - | Tecos Fútbol Club | 1:2 | ||||
| 17. Round | 20/02/2021 | Mineros de Fresnillo FC | - | Atlético San Luis II | 1:2 | ||||
| 18. Round | 05/03/2021 | Atlético San Luis II | - | Mazorqueros | 2:1 |
Mexico