| 1. Round | 27/03/2022 | Deportivo Cuenca [Women] | - | Leones del Norte [Women] | 0:3 | ||||
| 2. Round | 03/04/2022 | Deportivo Cuenca [Women] | - | Emelec [Women] | 3:5 |  |
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| 3. Round | 15/04/2022 | Espuce FC [Women] | - | Deportivo Cuenca [Women] | 2:0 | ||||
| 6. Round | 08/05/2022 | Deportivo Cuenca [Women] | - | Ñañas [Women] | 1:3 | ||||
| 9. Round | 28/05/2022 | Emelec [Women] | - | Deportivo Cuenca [Women] | 3:1 | ||||
| 10. Round | 04/06/2022 | Deportivo Cuenca [Women] | - | Espuce FC [Women] | 1:3 | ||||
| 14. Round | 06/08/2022 | Deportivo Cuenca [Women] | - | Quito FC [Women] | 1:4 |
Ecuador