| 2. Round | 14/08/2021 | Victoria Rosport | - | FC Differdange 03 | 0:3 |  |
|||
| 1. Round | 18/08/2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 | ||||
| 3. Round | 22/08/2021 | FC Differdange 03 | - | CS FOLA Esch | 1:1 | |
|||
| 4. Round | 29/08/2021 | UNA Strassen | - | FC Differdange 03 | 0:1 | ||||
| 5. Round | 12/09/2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 | ||||
| 6. Round | 19/09/2021 | FC Rodange 91 | - | FC Differdange 03 | 1:4 | ||||
| 7. Round | 22/09/2021 | FC Differdange 03 | - | RM Hamm Benfica | 3:0 | ||||
| 8. Round | 26/09/2021 | FC Wiltz 71 | - | FC Differdange 03 | 2:1 | |
|||
| 9. Round | 17/10/2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 |  |
|||
| 10. Round | 24/10/2021 | Jeunesse Esch | - | FC Differdange 03 | 0:0 | ||||
| 11. Round | 07/11/2021 | FC Differdange 03 | - | US Hostert | 1:4 |
Belgium