| 1. Round | 17/03/2018 | Rio Grande Valley FC | - | Saint Louis FC | 1:1 | ||||
| 1. Round | 25/03/2018 | San Antonio FC | - | Saint Louis FC | 2:1 | ||||
| 1. Round | 31/03/2018 | Saint Louis FC | - | Colorado Springs Switchbacks | 1:0 | ||||
| 2. Round | 08/04/2018 | Saint Louis FC | - | Fresno FC | 1:1 | ||||
| 2. Round | 15/04/2018 | Saint Louis FC | - | Los Angeles Galaxy II | 1:0 | ||||
| 6. Round | 26/08/2018 | Saint Louis FC | - | Tulsa Roughnecks | 3:2 | ||||
| 6. Round | 30/08/2018 | Seattle Sounders 2 | - | Saint Louis FC | 1:1 | ||||
| 7. Round | 02/09/2018 | Portland Timbers 2 | - | Saint Louis FC | 1:0 | ||||
| 7. Round | 09/09/2018 | Saint Louis FC | - | Reno 1868 FC | 1:0 | ||||
| 7. Round | 13/09/2018 | Real Monarchs SLC | - | Saint Louis FC | 1:1 | ||||
| 7. Round | 15/09/2018 | Swope Park Rangers | - | Saint Louis FC | 3:4 |  |
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| 7. Round | 23/09/2018 | Saint Louis FC | - | San Antonio FC | 2:0 | ||||
| 8. Round | 11/10/2018 | Saint Louis FC | - | Tulsa Roughnecks | 1:0 | ||||
| 8. Round | 14/10/2018 | Saint Louis FC | - | OKC Energy FC | 0:0 |
USA