| 3. Round | 26/06/2021 | Rio Grande Valley FC | - | FC Tulsa | 1:2 | ||||
| 4. Round | 03/07/2021 | OKC Energy FC | - | FC Tulsa | 0:0 | ||||
| 4. Round | 11/07/2021 | FC Tulsa | - | Louisville City FC | 3:2 | ||||
| 4. Round | 18/07/2021 | FC Tulsa | - | OKC Energy FC | 1:2 | ||||
| 4. Round | 25/07/2021 | Memphis 901 | - | FC Tulsa | 1:0 | ||||
| 4. Round | 29/07/2021 | Atlanta United II | - | FC Tulsa | 2:1 | ||||
| 6. Round | 09/09/2021 | FC Tulsa | - | Indy Eleven | 2:1 | ||||
| 6. Round | 12/09/2021 | FC Tulsa | - | Birmingham Legion | 1:1 | ||||
| 6. Round | 19/09/2021 | FC Tulsa | - | Austin Bold | 0:1 | ||||
| 6. Round | 25/09/2021 | Sporting Kansas City 2 | - | FC Tulsa | 1:1 | ||||
| 7. Round | 03/10/2021 | FC Tulsa | - | Memphis 901 | 0:3 | ||||
| 7. Round | 17/10/2021 | San Antonio FC | - | FC Tulsa | 1:1 | ||||
| 7. Round | 21/10/2021 | FC Tulsa | - | Atlanta United II | 4:0 |  |
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| 7. Round | 24/10/2021 | Indy Eleven | - | FC Tulsa | 1:1 | ||||
| 7. Round | 28/10/2021 | Memphis 901 | - | FC Tulsa | 3:2 | ||||
| 7. Round | 31/10/2021 | FC Tulsa | - | OKC Energy FC | 2:0 |
USA