| 28. Round | 18/08/2021 | El Nacional | - | Guayaquil SC | 3:1 | ||||
| 33. Round | 22/09/2021 | Chacaritas FC | - | Guayaquil SC | 4:1 | ||||
| 34. Round | 01/10/2021 | Guayaquil SC | - | América de Quito | 1:0 | ||||
| 35. Round | 06/10/2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Round | 13/10/2021 | Guayaquil SC | - | Atlético Porteño | 4:3 |  |
Ecuador