| 2. Round | 30/07/2021 | Arsenal Tula | - | Rubin Kazan | 0:3 | ||||
| 3. Round | 07/08/2021 | Arsenal Tula | - | Krylia Sovetov | 2:1 | ||||
| 4. Round | 15/08/2021 | FK Krasnodar | - | Arsenal Tula | 3:2 |  |
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| 9. Round | 27/09/2021 | FK Ural | - | Arsenal Tula | 2:0 | |
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| 11. Round | 16/10/2021 | Arsenal Tula | - | Zenit St. Petersburg | 2:1 | ||||
| 12. Round | 23/10/2021 | FK Rostov | - | Arsenal Tula | 4:0 | ||||
| 14. Round | 06/11/2021 | Arsenal Tula | - | FK Ufa | 0:0 | ||||
| 18. Round | 11/12/2021 | CSKA Moskva | - | Arsenal Tula | 2:0 |
Sweden