| 1. Round | 04/06/2022 | River Plate II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Round | 09/06/2022 | Atlético Tucumán II | - | River Plate II | 1:0 | ||||
| 3. Round | 14/06/2022 | River Plate II | - | Colón de Santa Fe II | 0:2 | ||||
| 4. Round | 18/06/2022 | River Plate II | - | Unión de Santa Fe II | 2:0 |  |
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| 5. Round | 24/06/2022 | Lanús II | - | River Plate II | 1:5 | ||||
| 6. Round | 02/07/2022 | River Plate II | - | Huracán II | 1:0 | ||||
| 7. Round | 09/07/2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 13. Round | 11/08/2022 | Newell's Old Boys II | - | River Plate II | 2:0 | ||||
| 14. Round | 16/08/2022 | River Plate II | - | Arsenal de Sarandí II | 0:0 | ||||
| 15. Round | 23/08/2022 | Central Córdoba SdE II | - | River Plate II | 1:0 | ||||
| 16. Round | 28/08/2022 | River Plate II | - | Tigre II | 0:2 | ||||
| 17. Round | 03/09/2022 | Barracas Central II | - | River Plate II | 2:1 | ||||
| 19. Round | 15/09/2022 | Banfield II | - | River Plate II | 0:1 | ||||
| 20. Round | 19/09/2022 | River Plate II | - | San Lorenzo II | 1:0 | ||||
| 21. Round | 24/09/2022 | Talleres de Córdoba II | - | River Plate II | 5:0 | ||||
| 25. Round | 12/10/2022 | Platense II | - | River Plate II | 0:1 | ||||
| 27. Round | 20/10/2022 | River Plate II | - | Racing Club II | 1:2 |
Argentina