| 1. Round | 09/01/2021 | Atlas Guadalajara [U20] | - | CF Monterrey [U20] | 0:2 | ||||
| 5. Round | 06/02/2021 | CF Monterrey [U20] | - | Pumas UNAM [U20] | 0:3 | ||||
| 6. Round | 14/02/2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 1:2 |  |
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| 8. Round | 28/02/2021 | CF Monterrey [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 9. Round | 03/03/2021 | FC Juárez [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 10. Round | 06/03/2021 | CF Monterrey [U20] | - | Gallos Blancos [U20] | 5:1 | ||||
| 3. Round | 10/03/2021 | CF Monterrey [U20] | - | Club León [U20] | 0:0 | ||||
| 11. Round | 13/03/2021 | Cruz Azul [U20] | - | CF Monterrey [U20] | 1:3 | ||||
| 12. Round | 20/03/2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 4. Round | 07/04/2021 | Puebla FC [U20] | - | CF Monterrey [U20] | 2:3 | ||||
| 14. Round | 11/04/2021 | Deportivo Toluca [U20] | - | CF Monterrey [U20] | 1:0 | ||||
| 15. Round | 18/04/2021 | CF Monterrey [U20] | - | CF Pachuca [U20] | 2:1 |
Mexico