4. Round | 21/02/2021 | Club Nacional | - | Libertad | 0:3 | ||||
2. Round | 24/02/2021 | Guaireña FC | - | Libertad | 1:0 | ||||
10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
12. Round | 18/04/2021 | Cerro Porteño | - | Libertad | 0:3 | ||||
13. Round | 26/04/2021 | Libertad | - | Club Nacional | 1:1 | ||||
14. Round | 04/05/2021 | River Plate | - | Libertad | 1:3 | ||||
15. Round | 09/05/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:1 | ||||
16. Round | 17/05/2021 | Guaraní | - | Libertad | 1:6 | ||||
17. Round | 22/05/2021 | Libertad | - | Sol de América | 1:2 | ||||
18. Round | 29/05/2021 | Sportivo Luqueño | - | Libertad | 1:3 |