| Round of 16 | 30/06/2022 | Deportivo Táchira | - | Santos FC | 1:1 | ||||
| Round of 16 | 07/07/2022 | Santos FC | - | Deportivo Táchira | 2:4 pso |  |
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| Quarter-finals | 03/08/2022 | Deportivo Táchira | - | Independiente del Valle | 0:1 | |
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| Quarter-finals | 10/08/2022 | Independiente del Valle | - | Deportivo Táchira | 4:1 | |
Panama