| 3. Round | 04/09/2000 | Telstar | - | Go Ahead Eagles | 2:0 | ||||
| 4. Round | 10/09/2000 | HFC Haarlem | - | Telstar | 2:2 | ||||
| 5. Round | 17/09/2000 | Telstar | - | SC Cambuur | 3:3 | ||||
| 6. Round | 25/09/2000 | Helmond Sport | - | Telstar | 1:2 | ||||
| 9. Round | 21/10/2000 | Telstar | - | Heracles Almelo | 2:1 | ||||
| 11. Round | 04/11/2000 | Telstar | - | FC Zwolle | 1:3 | ||||
| 17. Round | 16/12/2000 | ADO Den Haag | - | Telstar | 0:0 |  |
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| 18. Round | 30/01/2001 | SBV Excelsior | - | Telstar | 4:2 | ||||
| 20. Round | 10/02/2001 | Go Ahead Eagles | - | Telstar | 1:1 | ||||
| 21. Round | 17/02/2001 | Telstar | - | BV Emmen | 0:1 | ||||
| 23. Round | 04/03/2001 | Telstar | - | HFC Haarlem | 0:1 | ||||
| 24. Round | 10/03/2001 | Dordrecht '90 | - | Telstar | 5:0 | ||||
| 22. Round | 24/03/2001 | SC Cambuur | - | Telstar | 3:0 | |
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| 26. Round | 01/04/2001 | FC Den Bosch | - | Telstar | 1:0 | ||||
| 33. Round | 19/05/2001 | Heracles Almelo | - | Telstar | 0:1 | ||||
| 34. Round | 26/05/2001 | Telstar | - | SBV Eindhoven | 1:1 |  |
Netherlands