| 3. Round | 25/04/2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 9. Round | 06/06/2021 | Deportes Iquique | - | Universidad de Concepción | 5:1 | ||||
| 10. Round | 09/07/2021 | Cobreloa | - | Deportes Iquique | 3:2 | ||||
| 11. Round | 15/07/2021 | Unión San Felipe | - | Deportes Iquique | 3:1 | ||||
| 12. Round | 24/07/2021 | Deportes Iquique | - | Santiago Morning | 1:2 |  |
|||
| 2. Round | 29/07/2021 | Fernández Vial | - | Deportes Iquique | 0:1 | ||||
| 15. Round | 15/08/2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 18. Round | 02/09/2021 | San Marcos | - | Deportes Iquique | 4:2 | |
|||
| 20. Round | 16/09/2021 | San Luis | - | Deportes Iquique | 1:1 | ||||
| 21. Round | 23/09/2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | ||||
| 22. Round | 27/09/2021 | CD Magallanes | - | Deportes Iquique | 2:2 | ||||
| 26. Round | 20/10/2021 | Deportes Iquique | - | Unión San Felipe | 1:0 |
Chile